Amre Moussa a été notamment ministre des Affaires étrangères (1991-2001) et secrétaire général de la Ligue des Etats arabes (2001-2011).

He ran for President of Egypt in the first democratic elections following the 25th of January Revolution as an independent candidate with a vision for democracy and a firm call for reforming Egypt's bureaucratic and economic infrastructure. He lost the elections but continued his political career and was elected member of the Constitutional Assembly of 2012. He led the Liberal members' efforts to produce a liberal constitution, and then led a collective withdrawal protesting attempts to monopolize the drafting of the constitution.

Moussa founded the Congress party of Egypt and was the convener of the meeting of the Egyptian opposition that launched the National Salvation Front on the same day the “Constitutional” decree of November 2012 was issued by ex-President Morsi. Moussa called all political forces to immediately organize the opposition to the decree.  He played a principal role in the popular move that caused it to be retracted.
Amre Moussa a été l'un des dirigeants de la révolte qui a contribué à des plans d'une réforme qui a démarré avec les amendements à la Constitution de 2012 et l'organisation des élections présidentielle et parlementaires. Il a été élu président du Comité chargé d'amender la Constitution.

Amre Moussa continue de travailler avec plusieurs laboratoires de réflexion arabes et internationaux. En Egypte, il a été élu président du conseil d'administration de l'Université du Nil, de même que membre de ceux de l'Université britannique et de la Bibliothèque d'Alexandrie. Il a aussi lancé l'association pour protéger la Constitution, une organisation de la société civile. Il est membre du conseil d'institutions en Irak et en Azerbaïdjan.

He is the chairman of the High-Level Advisory Council Of the High Representative for The United Nations Alliance of Civilization.

He was awarded the Order of the Nile from Egypt, the Order of the Two Niles from the Sudanese Republic, the Supreme Order of the Renaissance from the Hashemite Kingdom of Jordan, a high order from the State of Qatar, the rank of Commander First Class of the Royal Order of the Polar Star of Sweden , in addition to orders and decorations from Brazil, Argentina, Germany, Ecuador and Venezuela.